Senior Scientist, Biology

Company Summary FL106 Inc. is a privately held, early-stage biotechnology company focused on developing novel drug delivery modalities. FL106 is backed by Flagship Pioneering, which provides the strategic vision and resources to advance FL106 from platform validation to clinical impact. Position Summary We are seeking a highly motivated and experienced Senior Scientist to join our research team. The successful candidate will possess deep expertise in cell isolation and sorting, in vivo/ in vitro mouse studies, gene-silencing technologies (siRNA), flow cytometry and advanced microscopy techniques. This individual will play a key role in designing, executing, and interpreting preclinical studies to therapeutic programs. Depending on experience and demonstrated leadership, the candidate may lead research initiatives, mentor team members, manage external collaborations, and contribute to scientific and program strategy. Key Responsibilities Design, execute, and analyze complex in vitro and ex vivo experiments to support discovery and preclinical research programs. Lead and perform multi-parameter flow cytometry assays, including panel design, optimization, troubleshooting, and data interpretation. Perform and optimize cell isolation and cell sorting (e.g., FACS, MACS) from various tissues and biological samples. Execute in vivo mouse studies, including disease model development, dosing, tissue collection, and phenotypic characterization. Develop and apply siRNA-based approaches for target validation, pathway interrogation, and mechanistic studies. Design and perform microscopy-based experiments, including fluorescence, confocal, live-cell, and high-content imaging, and analyze imaging datasets. Utilize complementary molecular and cellular biology techniques to support target validation and mechanism-of-action studies. Design, analyze, and interpret cell profiling experiments using flow cytometry, imaging, and molecular approaches. Contribute to biomarker discovery, translational research efforts, and preclinical candidate characterization. Analyze, interpret, and present experimental findings to cross-functional teams and senior leadership. Generate technical reports, presentations, study summaries, and scientific documentation to support program advancement. Collaborate effectively with internal teams, CROs, academic collaborators, and external partners. Mentor junior scientists and contribute to a collaborative, innovative research environment. For Senior Scientist and Principal Scientist levels, provide scientific leadership, contribute to research strategy, and lead cross-functional initiatives. Maintain accurate experimental records and ensure compliance with institutional, ethical, and regulatory guidelines. Qualifications Ph.D. in Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Biomedical Sciences, or a related field with 6+ years of relevant experience for Senior Scientist roles; 8+ years of industry experience and demonstrated scientific leadership for Principal Scientist roles. Alternatively, an M.S. degree with substantial relevant industry experience. Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis using FlowJo or equivalent software. Hands-on experience with cell isolation techniques, including tissue dissociation and magnetic bead-based separation. Extensive experience with mouse models and in vitro experimental techniques. Demonstrated expertise in siRNA design, delivery, optimization, and functional validation. Hands-on experience with microscopy platforms, including fluorescence, confocal, live-cell, and high-content imaging systems. Strong quantitative data analysis, experimental design, and statistical analysis skills. Excellent communication, presentation, and scientific writing skills. Ability to work independently and collaboratively in a fast-paced, multidisciplinary environment. Preferred Qualifications Experience in tr